Depression

Overview 

Depression is more than simply feeling unhappy or fed up for a few days.

Most people go through periods of feeling down, but when you're depressed you feel persistently sad for weeks or months, rather than just a few days.

Some people think depression is trivial and not a genuine health condition. They're wrong – it is a real illness with real symptoms. Depression is not a sign of weakness or something you can "snap out of" by "pulling yourself together".

Symptoms

Depression affects people in different ways and can cause a wide variety of symptoms.

They range from lasting feelings of unhappiness and hopelessness, to losing interest in the things you used to enjoy and feeling very tearful. Many people with depression also have symptoms of anxiety.

There can be physical symptoms too, such as feeling constantly tired, sleeping badly, having no appetite or sex drive, and various aches and pains.

Source: NHS

Research Summary
 
World icon.png
1,254

Depression trials open globally

UK icon.png
51

Depression trials open in the UK

icons8-group-96.png
17, 699

Participants required for UK studies

Global trials - phase

Phase indicates how far along the treatment is in the development process. Phase 1 indicates very early, phase 4 is later.

Global trials - interventions

Intervention is the type of treatment that will be being tested during the trial.

Screenshot 2021-10-19 at 13.21.43.png
 
Nye Spotlight Trials
Psilocybin in Depression Resistant to Standard Treatments
icons8-graduation-cap-90.png

Study type: interventional

icons8-users-64.png

60 estimated participants

icons8-calendar-100.png

Recruitment ends 2023-11-01

icons8-map-128.png

Clinical Research Facility, King's College Hospital, London

About this study

A single centre clinical trial to evaluate the feasibility, safety and efficacy of psilocybin, given under supportive conditions, in a randomised...

Eligibility

Inclusion Criteria:

  • Age 25 - 80 years

  • Fluent in the English language

  • Fulfil Diagnostic and Statistical Manual of Mental...

 

Alpha-Stim AID and Major Depressive Disorder
icons8-graduation-cap-90.png

Study type: interventional

icons8-users-64.png

230 estimated participants

icons8-calendar-100.png

Recruitment ends 2022-12-31

icons8-map-128.png

University of Nottingham, Nottingham

About this study

The study will be a multi-centre parallel group, double blind, non-commercial, randomised controlled superiority trial. Study participants will be referred from...

Eligibility

Inclusion Criteria:

  • Aged 16 years and above. There is no maximum age limit.

  • Diagnosis of current Major Depressive Episode...

Neural Mechanisms With CES in Depression
icons8-graduation-cap-90.png

Study type: interventional

icons8-users-64.png

60 estimated participants

icons8-calendar-100.png

Recruitment ends 2023-12-31

icons8-map-128.png

Oxford Brooke University, Oxford

About this study

This study will examine the effect of cranial electrotherapy stimulation (CES) treatment on adults with depression. Scalp based electroenc...

Eligibility

Inclusion Criteria:

  • Male or female subjects, 18 to 65 years of age.

  • Each subject must have a level of understanding sufficient to agree to all required tests and examinations and sign an informed consent document....

 

A Study to Assess Effectiveness and Efficiency of VNS Therapy in Patients With Difficult to Treat Depression.
icons8-graduation-cap-90.png

Study type: observational

icons8-users-64.png

500 estimated participants

icons8-calendar-100.png

Recruitment ends 2025-12-01

icons8-map-128.png
  • Glenfield hospital, Leicester

  • King's College London, London

  • Wolfson Research Centre, Newcastle

  • Mendip HTT / St Andrew's Ward, Wells

About this study

The primary objective of this study is to assess short, mid and long-term clinical outcomes in patients with difficult to treat depression (such as patients...

Eligibility

Be at least 18 years of age.
Have a documented primary diagnosis of chronic (>2 years) or recurrent (2 or more prior episodes) major depressive episode that has not adequately responded to an adequate number of antidepressant treatments, as per local...

Antidepressant Trial With P2X7 Antagonist JNJ-54175446
icons8-graduation-cap-90.png

Study type: interventional

icons8-users-64.png

142 estimated participants

icons8-calendar-100.png

Recruitment ends 2022-06-30

icons8-map-128.png
  • Addenbroooke's Hospital, Cambridge

  • Cardiff University, Cardiff

  • Queen Elizabeth University Hospital, Glasgow

  • The Maurice Wohl Clinical Neuroscience Institute, London

  • Warneford Hospital, Oxford

About this study

Depression is one of the most important causes of disability in the world today, with major personal, social and economic costs. Although some moderately...

Eligibility

Inclusion Criteria:

  • Provided written informed consent

  • Between the age of 18 to 60 years inclusive

  • Meets the Diagnostic and statistical manual - 5 (DSM-5) diagnostic criteria for MDD without psychotic...